Pattern for alpha-thalassaemia in Yemeni sickle-cell-disease patients
AbstractA group of Yemeni patients with sickle-cell disease [SCD] and normal Hb AA individuals living in Riyadh were studied to determine the incidence of the alpha-gene molecular defect. Blood samples were obtained from 26 SCD patients and 19 controls [the Hb AA group]. In the SCD patients the frequency of single alpha-gene deletion [-alpha/alpha alpha] was 0.346, compared to 0.263 in the Hb AA group. The frequency of two gene deletion [-alpha/-alpha] was 0.231 [0.0 for the Hb AA group]. In one Hb AA case, a triple alpha-gene arrangement [alpha alpha alpha/alpha alpha] was found [frequency 0.053]. The results suggest that alpha-thalassaemia occurs frequently in Yemeni SCD patients. Further studies to determine the overall frequency of alpha-thalassaemia in the Republic of Yemen would be of value for patient management
El Hazmi, M.A. & Warsy, A.S. (1999). Pattern for alpha-thalassaemia in Yemeni sickle-cell-disease patients. EMHJ - Eastern Mediterranean Health Journal, 5 (6), 1159-1164, 1999 http://www.who.int/iris/handle/10665/118811
JournalEMHJ - Eastern Mediterranean Health Journal, 5 (6), 1159-1164, 1999
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