Human mutations and their detection by gene and linkage analysis, allele sharing and association methods
AbstractIt has been 20 years since DNA analysis was first used in the detection of sickle-cell anaemia. Here, techniques for detecting human mutations are reviewed. We describe direct detection of mutations using restriction enzyme analysis and polymerase chain reaction amplification to detect gene deletions, rearrangements and point mutations. Indirect detection of mutations include the use of DNA polymorphisms in linkage analysis
Phillips, J.A. & Hamid, R. (1999). Human mutations and their detection by gene and linkage analysis, allele sharing and association methods. EMHJ - Eastern Mediterranean Health Journal, 5 (6), 1140-1146, 1999 http://www.who.int/iris/handle/10665/118808
JournalEMHJ - Eastern Mediterranean Health Journal, 5 (6), 1140-1146, 1999
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