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dc.contributorNazmy, N.A.EN
dc.contributorKotb, S.M.EN
dc.contributorMokhtar, M.M.EN
dc.contributorIsmail, S.R.EN
dc.date.accessioned2014-06-17T10:31:31Z
dc.date.available2014-06-17T10:31:31Z
dc.date.issued1999EN
dc.identifier.issn1020-3397EN
dc.identifier.otherhttp://applications.emro.who.int/emhj/0502/EMHJ_1999_5_2_299_306.pdfEN
dc.identifier.urihttp://www.who.int/iris/handle/10665/118708
dc.description299-306EN
dc.description.abstractThe study aimed to evaluate the role of nucleolus organizer region [‎NOR]‎ heteromorphism as an etiological factor for parental nondisjunction in Down syndrome by comparing 25 patients affected by Down syndrome, and their parents with a control group of 80 non-affected Egyptians. All parents had normal karyotypes. The average modal number per parent of Ag-positive NORs was significantly higher in parents than controls. A significant difference in the size of the double-NOR variants [‎dNORs]‎ was found. The mean maternal and paternal ages were significantly lower, with a significant increase in spontaneous abortions, for dNOR[‎+]‎ couples compared with dNOR[‎-]‎ couplesEN
dc.language.isoenEN
dc.subjectAbortion, SpontaneousEN
dc.subjectCase-Control StudiesEN
dc.subjectDown SyndromeEN
dc.subjectInfant, NewbornEN
dc.subjectKaryotypingEN
dc.subjectMaternal AgeEN
dc.subjectNondisjunction, GeneticEN
dc.subjectPedigreeEN
dc.subjectPregnancyEN
dc.subject.meshNucleolus Organizer RegionEN
dc.titleNucleolus organizer region heteromorphism in patients with Down syndrome and their parentsEN
dc.relation.ispartofjournalEMHJ - Eastern Mediterranean Health Journal, 5 (‎2)‎, 299-306, 1999


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