Nucleolus organizer region heteromorphism in patients with Down syndrome and their parents
AbstractThe study aimed to evaluate the role of nucleolus organizer region [NOR] heteromorphism as an etiological factor for parental nondisjunction in Down syndrome by comparing 25 patients affected by Down syndrome, and their parents with a control group of 80 non-affected Egyptians. All parents had normal karyotypes. The average modal number per parent of Ag-positive NORs was significantly higher in parents than controls. A significant difference in the size of the double-NOR variants [dNORs] was found. The mean maternal and paternal ages were significantly lower, with a significant increase in spontaneous abortions, for dNOR[+] couples compared with dNOR[-] couples
Nazmy, N.A., Kotb, S.M., Mokhtar, M.M. & Ismail, S.R. (1999). Nucleolus organizer region heteromorphism in patients with Down syndrome and their parents. EMHJ - Eastern Mediterranean Health Journal, 5 (2), 299-306, 1999 http://www.who.int/iris/handle/10665/118708
JournalEMHJ - Eastern Mediterranean Health Journal, 5 (2), 299-306, 1999
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