Thalassaemia and glucose-6-phosphate dehydrogenase deficiency in sickle-cell disorder patients in Taiz, Yemen
النسخة الإلكترونية غير متاحة
عرض الإحصاءاتعرض الإحصاءات
الملخصA pilot study was conducted to determine the prevalence and haematological characteristics of the interaction between thalassaemia or/and glucose-6-phosphate dehydrogenase [G6PD] deficiency in patients with sickle-cell disorder [SCD] in Taiz city, Yemen, where the prevalence of sickle-cell trait [HbAS] is 8.2%. Blood samples were collected from 31 SCD patients. Complete blood count and haemoglobin electrophoresis, G6PD activity and serum ferritin were determined. Thalassaemia was found in 6 patients [19.4%] and G6PD deficiency [6 mild and 1 severe] was detected in 7 patients [22.6%] The frequency of thalassaemia and/or G6PD deficiency with SCD was high and this may have an effect on the seventy of the clinical course of SCD in Taiz. The study should be repeated with DNA analysis to define the nature of the globin gene defect and to clarify its role in the severity of SCD
Al Nood, H.A. (2011). Thalassaemia and glucose-6-phosphate dehydrogenase deficiency in sickle-cell disorder patients in Taiz, Yemen. EMHJ - Eastern Mediterranean Health Journal, 17 (5), 404-408, 2011 http://www.who.int/iris/handle/10665/118633
المجلةEMHJ - Eastern Mediterranean Health Journal, 17 (5), 404-408, 2011
البياناتعرض سجل كامل للمادة
مواد ذات صلة
عرض المواد ذات الصلة حسب العنوان، إسم المؤلف والموضوع.
مؤلف غير معروف (1995)Genetic disorders of haemoglobin are prevalent in Bahrain. In a study of the hospital population covering 56 198 Bahrainis, we found that 2% of newborns have sickle-cell disease [SCD] and 18% have sickle-cell trait, while 24% are carriers of the [-thalassaemia gene. In a study of the presentation of SCD among Bahrainis it was found that the mild form of the disease predominates, but a wide clinical variability is apparent. It was also found that their haematological values are similar to those of patients from Eastern Province, Saudi Arabia, where ...