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Peginterferon alfa-2b and ribavirin therapy in Kuwaiti patients with chronic hepatitis C virus infection
dc.contributor.author | Al Enzi, S.A. | |
dc.contributor.author | Ismail, W.A. | |
dc.contributor.author | Alsurayei, S.A. | |
dc.contributor.author | Ismail, A.E. | |
dc.date.accessioned | 2014-06-17T09:52:07Z | |
dc.date.available | 2014-06-17T09:52:07Z | |
dc.date.issued | 2011 | EN |
dc.identifier.issn | 1020-3397 | EN |
dc.identifier.other | http://applications.emro.who.int/emhj/V17/08/17_8_2011_0669_0678.pdf | EN |
dc.identifier.uri | https://iris.who.int/handle/10665/118282 | |
dc.description | 669-678 | EN |
dc.description.abstract | Few studies have been conducted in the Eastern Mediterranean region on chronic hepatitis C virus [HCV] infection with reference to genotypes. We investigated the response to standard combination therapy [pegylated interferon/ribavirin] of different genotypes of HCV in Kuwaiti patients and factors that could be associated with sustained virological response [SVR]. The records of all Kuwaiti patients treated for chronic HCV between January 2003 and May 2009 were retrospectively identified and reviewed. Of 108 patients studied, 27.8% were infected with genotype 1, 25.0% with genotype 3 and 47.2% with genotype 4. Overall, 64.8% of patients achieved SVR, 25.9%, were non-responders and 9.3% were relapsers. Baseline viral load and alanine aminotransferase level in addition to early virological response to pegylated interferon-based therapy may serve as a decision tool for clinicians to identify patients who are unlikely to achieve SVR | EN |
dc.language.iso | en | EN |
dc.subject | Interferon-alpha | EN |
dc.subject | Polyethylene Glycols | EN |
dc.subject | Ribavirin | EN |
dc.subject | Retrospective Studies | EN |
dc.subject | Treatment Outcome | EN |
dc.subject | Genotype | EN |
dc.subject | Viral Load | EN |
dc.subject.mesh | Hepatitis C, Chronic | EN |
dc.title | Peginterferon alfa-2b and ribavirin therapy in Kuwaiti patients with chronic hepatitis C virus infection | EN |
dc.relation.ispartofjournal | EMHJ - Eastern Mediterranean Health Journal, 17 (8), 669-678, 2011 |