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dc.contributor.authorAnwar, M.M.
dc.contributor.authorYoussef, A.I.
dc.contributor.authorSheta, M.I.
dc.contributor.authorZaki, A.
dc.contributor.authorBernaba, N.R.
dc.contributor.authorEl Toukhi, M.A.
dc.date.accessioned2014-06-17T09:51:05Z
dc.date.available2014-06-17T09:51:05Z
dc.date.issued2012EN
dc.identifier.issn1020-3397EN
dc.identifier.otherhttp://applications.emro.who.int/emhj/v18/05/18_5_2012_0501_0507.pdfEN
dc.identifier.urihttp://www.who.int/iris/handle/10665/118268
dc.description501-507EN
dc.description.abstractThe aim of the study was to assess the accuracy of some specific biochemical indicators in discriminating between Helicobacter pylori-associated gastritis and H. pylori-associated stomach cancer [‎serum gastrin level, serum soluble E-cadherin and tissue COX-2 activity, as well as serodiagnostic markers for H. pylori infection]‎ in order to find a simple diagnostic test that can reasonably predict the development of gastric cancer. The study participants comprised 20 patients with gastric carcinoma, 20 patients with positive H. pylori-associated gastritis and 20 individuals as the control group. Standard procedures and quality control measures were followed. Using cut-off values and ROC analysis to assess the diagnostic abilities of the biochemical indicators, E-cadherin showed the highest sensitivity [‎100%]‎. We suggest that close follow-up together with periodic endoscopic examination for all patients with persistent H. pylori infection and serum soluble E-cadherin level above 5 microg/mL is essentialEN
dc.language.isoenEN
dc.subjectStomach NeoplasmsEN
dc.subjectHelicobacter pyloriEN
dc.subjectGastrinsEN
dc.subjectCadherinsEN
dc.subjectStomach NeoplasmsEN
dc.subjectGastritisEN
dc.subjectSensitivity and SpecificityEN
dc.subject.meshStomach NeoplasmsEN
dc.titleEvaluation of specific biochemical indicators of Helicobactepylori-associated gastric cancer in EgyptEN
dc.relation.ispartofjournalEMHJ - Eastern Mediterranean Health Journal, 18 (‎5)‎, 501-507, 2012


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