dc.contributor.author | Anwar, M.M. | |
dc.contributor.author | Youssef, A.I. | |
dc.contributor.author | Sheta, M.I. | |
dc.contributor.author | Zaki, A. | |
dc.contributor.author | Bernaba, N.R. | |
dc.contributor.author | El Toukhi, M.A. | |
dc.date.accessioned | 2014-06-17T09:51:05Z | |
dc.date.available | 2014-06-17T09:51:05Z | |
dc.date.issued | 2012 | EN |
dc.identifier.issn | 1020-3397 | EN |
dc.identifier.other | http://applications.emro.who.int/emhj/v18/05/18_5_2012_0501_0507.pdf | EN |
dc.identifier.uri | https://iris.who.int/handle/10665/118268 | |
dc.description | 501-507 | EN |
dc.description.abstract | The aim of the study was to assess the accuracy of some specific biochemical indicators in discriminating between Helicobacter pylori-associated gastritis and H. pylori-associated stomach cancer [serum gastrin level, serum soluble E-cadherin and tissue COX-2 activity, as well as serodiagnostic markers for H. pylori infection] in order to find a simple diagnostic test that can reasonably predict the development of gastric cancer. The study participants comprised 20 patients with gastric carcinoma, 20 patients with positive H. pylori-associated gastritis and 20 individuals as the control group. Standard procedures and quality control measures were followed. Using cut-off values and ROC analysis to assess the diagnostic abilities of the biochemical indicators, E-cadherin showed the highest sensitivity [100%]. We suggest that close follow-up together with periodic endoscopic examination for all patients with persistent H. pylori infection and serum soluble E-cadherin level above 5 microg/mL is essential | EN |
dc.language.iso | en | EN |
dc.subject | Stomach Neoplasms | EN |
dc.subject | Helicobacter pylori | EN |
dc.subject | Gastrins | EN |
dc.subject | Cadherins | EN |
dc.subject | Stomach Neoplasms | EN |
dc.subject | Gastritis | EN |
dc.subject | Sensitivity and Specificity | EN |
dc.subject.mesh | Stomach Neoplasms | EN |
dc.title | Evaluation of specific biochemical indicators of Helicobactepylori-associated gastric cancer in Egypt | EN |
dc.relation.ispartofjournal | EMHJ - Eastern Mediterranean Health Journal, 18 (5), 501-507, 2012 | |