Evaluation of specific biochemical indicators of Helicobactepylori-associated gastric cancer in Egypt

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Abstract
The aim of the study was to assess the accuracy of some specific biochemical indicators in discriminating between Helicobacter pylori-associated gastritis and H. pylori-associated stomach cancer [serum gastrin level, serum soluble E-cadherin and tissue COX-2 activity, as well as serodiagnostic markers for H. pylori infection] in order to find a simple diagnostic test that can reasonably predict the development of gastric cancer. The study participants comprised 20 patients with gastric carcinoma, 20 patients with positive H. pylori-associated gastritis and 20 individuals as the control group. Standard procedures and quality control measures were followed. Using cut-off values and ROC analysis to assess the diagnostic abilities of the biochemical indicators, E-cadherin showed the highest sensitivity [100%]. We suggest that close follow-up together with periodic endoscopic examination for all patients with persistent H. pylori infection and serum soluble E-cadherin level above 5 microg/mL is essentialCitation
Anwar, M.M., Youssef, A.I., Sheta, M.I., Zaki, A., Bernaba, N.R. et al. (2012). Evaluation of specific biochemical indicators of Helicobactepylori-associated gastric cancer in Egypt. EMHJ - Eastern Mediterranean Health Journal, 18 (5), 501-507, 2012 https://apps.who.int/iris/handle/10665/118268