Immunoinflammatory markers and disease activity in systemic lupus erythematosus: something old, something new
AbstractThis study assessed the utility of some novel inflammatory markers compared with traditional laboratory markers in patients with systemic lupus erythematosus [SLE]. In a cohort of 43 SLE patients [19 with inactive and 24 with active SLE] and 20 healthy controls, serial measures of soluble vascular cell adhesion molecule [sVCAM-1] were significantly associated with SLE disease activity, scored using the British Isles Lupus Assessment Group index. Inflammatory markers neopterin and soluble intercellular adhesion molecule [sICAM-1] appeared to be clinically useful for isolated assessments of disease activity. Both antibodies to double-stranded DNA [antidsDNA] and sVCAM-1 were relatively good markers of disease activity and could help to predict remission or monitor the therapeutic response in SLE
Elwy, M.A., Galal, Z.A. & Hasan, H.E. (2010). Immunoinflammatory markers and disease activity in systemic lupus erythematosus: something old, something new. EMHJ - Eastern Mediterranean Health Journal, 16 (8), 893-900, 2010 http://www.who.int/iris/handle/10665/117956
JournalEMHJ - Eastern Mediterranean Health Journal, 16 (8), 893-900, 2010
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Tazi, I.; Fehri, S.; Elghrari, K.; Ouazzani, T.; Benchemsi, N. (2009)We determined the prevalence of antibodies to Epstein-Barr virus [EBV] in 44 patients with systemic lupus erythematosus [SLE] and 44 healthy blood donors matched for sex and age as controls. Of the cases, 39 were women; mean age was 33 years. Four cases [9%] and 5 controls [11%] were positive for IgM anti-viral capsid antigen [VCA] [P = 0.9]. All the cases were positive for IgG anti-VCA compared with 91% of the controls [P = 0.12]. The mean immunity ratio for this antibody was 2.341 in cases and 1.873 in controls [P = 0.068]. Forty [91%] cases ...