Comparison of the effectiveness of 2 treatment regimens in patients with isoniazid-resistant tuberculosis

Abstract

We compared the effectiveness of 2 treatment regimens for isoniazid-resistant tuberculosis [‎TB]‎ in 42 patients attending a TB referral centre in the Islamic Republic of Iran. The patients were divided into 2 treatment groups: 26 received the 6-month standard HRZE treatment and 16 received a modified treatment of RZE for 6 months. There were no significant differences in age or sex of the groups. With the standard method of treatment, 21 [‎80.8%]‎ patients were cured, 4 [‎15.4%]‎ resulted in treatment failure, and 1 [‎3.8%]‎ died. In the modified treatment group, 16 [‎100%]‎ patients were cured. These differences were not statistically significantly different [‎P = 0.194]‎