Antioxidant status and lipid peroxidation activity in evaluating hepatocellular damage in children
AbstractSerum levels of glutathione reductase [GR], glutathione S-transferase-alpha [GST-alpha] and malondialdehyde [MDA] were determined to evaluate their use in diagnosing hepatocellular damage in 75 children with liver disease. Except for level of GR in patients with HBV, GR, GST-alpha and MDA were raised significantly in patients compared with controls. At 100% specificity, the sensitivity of the 3 markers for detecting hepatitis B virus, hepatitis C virus and schistosomiasis infection respectively were: 16.7%, 100.0% and 17.7% for GR; 33.3%, 62.1% and 38.2% for GST-alpha; and 25.0%, 10.3% and 29.4% for MDA. GR was more sensitive in hepatitis C infection, while MDA reflected changes in liver ultrasound and GST-alpha was the best indicator for histopathological changes
Mahdy, K.A., Abdel Shaheed, A., Khadr, M.E. & El Shamy, K.A.I. (2009). Antioxidant status and lipid peroxidation activity in evaluating hepatocellular damage in children. EMHJ - Eastern Mediterranean Health Journal, 15 (4), 842-852, 2009 https://apps.who.int/iris/handle/10665/117705
JournalEMHJ - Eastern Mediterranean Health Journal, 15 (4), 842-852, 2009
MetadataShow full item record
Showing items related by title and subject
Trends in cardiovascular disease risk factors in children and adolescents: Tehran Lipid and Glucose Study Moradi, S.; Azizi, F. (2013)Studies have shown that cardiovascular risk factors, such as obesity, blood lipid levels, start early in childhood and some are on the rise in children. Data on trends are important in order to identify if there is a ...