T-cell cytokine production and endothelial dysfunction in type 2 diabetic patients with nephropathy

Abstract

This study assessed changes in serum levels of cytokines IFNgamma and IL-10 [‎biomarkers of inflammatory changes]‎ and soluble biomarkers sICAM-1 and sE-selectin [‎biomarkers of endothelial dysfunction]‎ in diabetic patients with and without nephropathy. IFNgamma and IL-10 were significantly elevated in patients with diabetic nephropathy [‎DN]‎ and end-stage renal disease [‎ESRD]‎ compared with controls and diabetic patients without DN. IFNgamma and IL-10 levels were significantly increased after haemodialysis. sICAM-1 and sE-selectin were significantly higher in diabetic, DN and ESRD groups compared with controls, and sICAM-1 but not sE-selectin was increased after haemodialysis