Combination therapy with interferon and ribavirin for chronic hepatitis C infection in beta-thalassaemia major
AbstractTreatment of chronic hepatitis C virus [HCV] infection in transfusion-dependent betathalassaemia major patients is complicated by existing hepatic siderosis and the fear of ribavirinassociated haemolysis. We evaluated the efficacy and side-effects of combination interferon-alpha [INF] and ribavirin therapy for HCV-infected thalassaemia patients. A total of 17 patients were enrolled [10 nonresponders to INF monotherapy, 7 naive to treatment, mean age 23.1 years] and they received 12 months of combination therapy. The sustained virological response rate 6 months after treatment was 58.8%. Blood transfusion requirements during treatment temporarily increased by 36.6%. Combination therapy was tolerated by, and may be useful for, HCV-infected thalassaemia major patients
Saffar, M.J., Saffar, H., Khalilian, A.R. & Naqshvar, F. (2009). Combination therapy with interferon and ribavirin for chronic hepatitis C infection in beta-thalassaemia major. EMHJ - Eastern Mediterranean Health Journal, 15 (4), 785-791, 2009 https://apps.who.int/iris/handle/10665/117699
JournalEMHJ - Eastern Mediterranean Health Journal, 15 (4), 785-791, 2009
MetadataShow full item record
Showing items related by title and subject
Genotype characterization of occult hepatitis B virus strains among Egyptian chronic hepatitis C patients Kishk, R.; Aboul Atta, H.; Ragheb, M.; Kamel, M.; Metwally, L.; Nemr, N. (World Health Organization, Regional Office for the Eastern Mediterranean, 2014)Chronic hepatitis C virus [HCV]infection combined with occult hepatitis B virus [HBV]infection has been associated with increased risk of hepatitis, cirrhosis and hepatocellular carcinoma.This study aimed to determine the ...
John, A.K.; Al Kaabi, S.; John, A.; Singh, R.; Derbala, M. (2010)Hepatitis C virus [HCV] infection is a major public health problem in the Middle East. A database of 400 patients with chronic HCV in Qatar was retrospectively analysed: 242 patients underwent antiviral treatment, of whom ...
Peginterferon alfa-2b and ribavirin therapy in Kuwaiti patients with chronic hepatitis C virus infection Al Enzi, S.A.; Ismail, W.A.; Alsurayei, S.A.; Ismail, A.E. (2011)Few studies have been conducted in the Eastern Mediterranean region on chronic hepatitis C virus [HCV] infection with reference to genotypes. We investigated the response to standard combination therapy [pegylated ...