C-reactive protein: a useful marker for guiding duration of antibiotic therapy in suspected neonatal septicaemia?
AbstractThe study aimed to determine whether serum C-reactive protein [CRP] levels can be used to identify when antibiotics can safely be discontinued in cases of suspected neonatal septicaemia. Neonates with suspected neonatal septicaemia treated at a hospital in Al Ramadi city, Iraq, in 2005 had serum CRP and blood cultures [the gold standard] done at admission and at 48 hours, 4 days and 6 days after starting treatment. Of the 55 neonates, CRP was </= 6 mg/L at 48 hours in 37 [67.3%] and antibiotics could be stopped in 32 [82.5%], i.e. when blood culture was negative. The moderate sensitivity [78%] and negative predictive value [86%] of serum CRP in this study suggest that this test alone cannot be used for guiding duration of antibiotic treatment for neonatal sepsis
Al Zwaini, E.J. (2009). C-reactive protein: a useful marker for guiding duration of antibiotic therapy in suspected neonatal septicaemia?. EMHJ - Eastern Mediterranean Health Journal, 15 (2), 269-275, 2009 http://www.who.int/iris/handle/10665/117635
JournalEMHJ - Eastern Mediterranean Health Journal, 15 (2), 269-275, 2009
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Yilmaz, N.; Cicek, H.K.; Celik, A.; Meram, I.; Kocabas, R.; Davutoglu, V. (2007)We evaluated 3 new markers for coronary artery disease [CAD] [bilirubin, total homocysteine [t-Hcy] and high-sensitivity C-reactive protein [hs-CRP]] in 319 patients with chest pains divided into 2 groups based on coronary angiography: CAD group [n = 262] and non-CAD group [n = 57]. A control group consisted of 50 healthy subjects. t-Hcy had the highest diagnostic value for diagnosis of angiographically documented patients; bilirubin had the lowest. The sensitivities and specificities [based on ROC curves] of bilirubin, hs-CRP and t-Hcy were ...