C-reactive protein: a useful marker for guiding duration of antibiotic therapy in suspected neonatal septicaemia?
AbstractThe study aimed to determine whether serum C-reactive protein [CRP] levels can be used to identify when antibiotics can safely be discontinued in cases of suspected neonatal septicaemia. Neonates with suspected neonatal septicaemia treated at a hospital in Al Ramadi city, Iraq, in 2005 had serum CRP and blood cultures [the gold standard] done at admission and at 48 hours, 4 days and 6 days after starting treatment. Of the 55 neonates, CRP was </= 6 mg/L at 48 hours in 37 [67.3%] and antibiotics could be stopped in 32 [82.5%], i.e. when blood culture was negative. The moderate sensitivity [78%] and negative predictive value [86%] of serum CRP in this study suggest that this test alone cannot be used for guiding duration of antibiotic treatment for neonatal sepsis
Al Zwaini, E.J. (2009). C-reactive protein: a useful marker for guiding duration of antibiotic therapy in suspected neonatal septicaemia?. EMHJ - Eastern Mediterranean Health Journal, 15 (2), 269-275, 2009 https://apps.who.int/iris/handle/10665/117635