Study of aerobic granulocyte functional activity in the presence of a radiosensitizer [metronidazole]

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Abstract
The in vitro effects of metronidazole on the production of reactive oxygen species by polymorphonuclear [PMN] cells were studied by means of nitroblue tetrazolium and luminol-dependent chemiluminescence. At therapeutic doses of metronidazole [4.98-24.86 microg/mL] significant inhibition of the production of reactive oxygen species was noted in both methods. The inhibitory effect was in a dose-dependent pattern. The data suggest a scavenging mechanism of metronidazole on reactive oxygen species generated by PMNCitation
Al Krawi, E.A.A. & Al Hashimi, A.H.M. (2009). Study of aerobic granulocyte functional activity in the presence of a radiosensitizer [metronidazole]. EMHJ - Eastern Mediterranean Health Journal, 15 (1), 224-229, 2009 https://apps.who.int/iris/handle/10665/117630