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dc.contributorHosseini Mazinani, S.M.EN
dc.contributorKoochmeshgi, J.EN
dc.contributorKhazaee Koohpar, Z.EN
dc.contributorHosein Pur Nobari, N.EN
dc.contributorSeifati, S.M.EN
dc.date.accessioned2014-06-17T08:32:38Z
dc.date.available2014-06-17T08:32:38Z
dc.date.issued2008EN
dc.identifier.issn1020-3397EN
dc.identifier.otherhttp://applications.emro.who.int/emhj/1406/14_6_2008_1445_1451.pdfEN
dc.identifier.urihttp://www.who.int/iris/handle/10665/117576
dc.description1445-1451EN
dc.description.abstractThis study of Iranian families assessed the usefulness of carrier detection of phenylketonuria by variable number tandem-repeat [‎VNTR]‎ polymorphism analysis. We studied 171 people [‎45 unrelated PKU subjects, and their parents and unaffected siblings]‎. Of 342 chromosomes [‎131 non-PKU and 211 PKU]‎, 5 VNTR alleles were identified. This VNTR system would yield a polymorphism information content of 66%, comparable to that in Europeans and higher than in Chinese. Carrier detection by segregation analysis of VNTR was informative in 89.5% of siblings. We conclude that this polymorphism is highly informative in carrier detection of PKU in the Iranian populationEN
dc.language.isoenEN
dc.subjectPhenylketonuriasEN
dc.subjectPolymorphism, GeneticEN
dc.subjectTandem Repeat SequencesEN
dc.subjectCarrier StateEN
dc.subjectCarrier StateEN
dc.subjectFamilyEN
dc.subjectPolymerase Chain ReactionEN
dc.subject.meshPhenylketonuriasEN
dc.titleCarrier detection of phenylketonuria in Iranian families by variable number tandem-repeat polymorphism analysisEN
dc.relation.ispartofjournalEMHJ - Eastern Mediterranean Health Journal, 14 (‎6)‎, 1445-1451, 2008


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