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dc.contributorHosseini Mazinani, S.M.EN
dc.contributorKoochmeshgi, J.EN
dc.contributorKhazaee Koohpar, Z.EN
dc.contributorHosein Pur Nobari, N.EN
dc.contributorSeifati, S.M.EN
dc.date.accessioned2014-06-17T08:32:38Z
dc.date.available2014-06-17T08:32:38Z
dc.date.issued2008EN
dc.identifier.issn1020-3397EN
dc.identifier.otherhttp://applications.emro.who.int/emhj/1406/14_6_2008_1445_1451.pdfEN
dc.identifier.urihttp://www.who.int/iris/handle/10665/117576
dc.description1445-1451EN
dc.description.abstractThis study of Iranian families assessed the usefulness of carrier detection of phenylketonuria by variable number tandem-repeat [‎VNTR]‎ polymorphism analysis. We studied 171 people [‎45 unrelated PKU subjects, and their parents and unaffected siblings]‎. Of 342 chromosomes [‎131 non-PKU and 211 PKU]‎, 5 VNTR alleles were identified. This VNTR system would yield a polymorphism information content of 66%, comparable to that in Europeans and higher than in Chinese. Carrier detection by segregation analysis of VNTR was informative in 89.5% of siblings. We conclude that this polymorphism is highly informative in carrier detection of PKU in the Iranian populationEN
dc.language.isoenEN
dc.relation.ispartofseriesEMHJ - Eastern Mediterranean Health Journal, 14 (‎6)‎, 1445-1451, 2008EN
dc.subjectPhenylketonuriasEN
dc.subjectPolymorphism, GeneticEN
dc.subjectTandem Repeat SequencesEN
dc.subjectCarrier StateEN
dc.subjectCarrier StateEN
dc.subjectFamilyEN
dc.subjectPolymerase Chain ReactionEN
dc.subject.meshPhenylketonuriasEN
dc.titleCarrier detection of phenylketonuria in Iranian families by variable number tandem-repeat polymorphism analysisEN


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