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dc.contributor.authorRadwan, A.S.
dc.contributor.authorMostafa, I.
dc.date.accessioned2014-06-17T08:28:55Z
dc.date.available2014-06-17T08:28:55Z
dc.date.issued2008EN
dc.identifier.issn1020-3397EN
dc.identifier.otherhttp://applications.emro.who.int/emhj/1406/14_6_2008_1301_1307.pdfEN
dc.identifier.urihttps://apps.who.int/iris/handle/10665/117558
dc.description1301-1307EN
dc.description.abstractAdrenal androgens, particularly dehydroepiandrosterone [‎DHEA]‎, may have important regulatory effects on the immune system in humans. This study measured the changes in adrenal steroidogenesis in 13 non-infected cirrhosis patients with sterile ascites and 13 patients with spontaneous bacterial peritonitis and the relation with circulating interleukin-6 [‎IL-6]‎ levels. Comparisons were made with 10 healthy age-matched control subjects. The severity of bacterial peritonitis in liver cirrhosis was significantly associated with enhanced serum IL-6 and cortisol levels, and a decrease in serum DHEA sulfate in relation to serum IL-6 concentrations. Careful, long-term studies on DHEA administered to cirrhosis patients are needed to assess its safety in improving a number of pathological conditions that complicate liver cirrhosisEN
dc.language.isoenEN
dc.subjectDehydroepiandrosteroneEN
dc.subjectAdrenal MedullaEN
dc.subjectAndrogensEN
dc.subjectPeritonitisEN
dc.subjectPeritonitisEN
dc.subjectAscitesEN
dc.subjectInterleukin-6 ; analysisEN
dc.subjectLiver CirrhosisEN
dc.subject.meshDehydroepiandrosteroneEN
dc.titleChanges in adrenal steroidogenesis in spontaneous bacterial peritonitis and sterile ascitesEN
dc.relation.ispartofjournalEMHJ - Eastern Mediterranean Health Journal, 14 (‎6)‎, 1301-1307, 2008


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