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Effect of methoxyverapamil, diltiazem, morphine and their combination on the formation of irreversibly sickled cells: an in vitro study

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Abstract
The effect of methoxyverapamil and diltiazem [‎calcium antagonists]‎ and morphine [‎calcium antagonist activity]‎ on the formation of irreversibly sickled cells [‎ISCs]‎ was investigated. Methoxyverapamil at therapeutic concentration and 10 times that level resulted in a 12% and 21% reduction in the formation of ISCs respectively, which was statistically significant. Diltiazem also produced a significant reduction in ISCs but morphine produced no significant reduction. Combination of these drugs produced a net effect similar to their individual effects. These drugs might be useful in decreasing the intensity of sickling crises and vaso-occlusive events. Thus in vivo trials in patients with sickle-cell disease are suggested
Citation
Ahmed, Jawad H., Al Diwan, Manal S. & Jawad, Abdullah M. (‎1997)‎. Effect of methoxyverapamil, diltiazem, morphine and their combination on the formation of irreversibly sickled cells: an in vitro study. http://www.who.int/iris/handle/10665/117373
Relation
EMHJ - Eastern Mediterranean Health Journal, 3 (‎2)‎, 301-309, 1997
Description
301-309
ISSN
1020-3397
Other Identifiers
http://applications.emro.who.int/emhj/0302/emhj_1997_3_2_301_309.pdf
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  • EMRO Journal Articles (‎EMHJ)‎
Language
English
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