Red cell alloimmunization in sickle-cell anaemia patients
AbstractThis study in King Fahd Hospital of the University, Saudi Arabia, assessed the frequency of alloimmunization to red cell antigens in sickle-cell anaemia patients over 1996-2004 in order to evaluate the risk of alloimmunization and identify the most common alloantibodies. A retrospective analysis of the transfusion history and medical records of 350 patients aged 2 to 75 years who had received at least 1 transfusion found that 48 patients had developed alloantibodies [13.7%]. The most common alloantibodies detected were: anti-E alone [18.8%], nonspecific [12.5%], inconclusive [12.5%], anti-K [10.4%] and anti-c 3 [6.3%]. Some patients had 1 alloantibody, while others more than 1 and even multiple antibodies. Nine patients had a persistent positive direct antiglobulin test
Bashawri, L.A.M. (2007). Red cell alloimmunization in sickle-cell anaemia patients. EMHJ - Eastern Mediterranean Health Journal, 13 (5), 1181-1189, 2007 http://www.who.int/iris/handle/10665/117364
JournalEMHJ - Eastern Mediterranean Health Journal, 13 (5), 1181-1189, 2007
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Al Arrayed, Sheikha S.; Haites, Neva (1995)Genetic disorders of haemoglobin are prevalent in Bahrain. In a study of the hospital population covering 56 198 Bahrainis, we found that 2% of newborns have sickle-cell disease [SCD] and 18% have sickle-cell trait, while 24% are carriers of the [-thalassaemia gene. In a study of the presentation of SCD among Bahrainis it was found that the mild form of the disease predominates, but a wide clinical variability is apparent. It was also found that their haematological values are similar to those of patients from Eastern Province, Saudi Arabia, where ...