Serum levels of astroglial S100-beta and neuron-specific enolase in hepatic encephalopathy patients
AbstractTo find a reliable, noninvasive method for the diagnosis of cognitive impairment in patients with hepatic cirrhosis we measured serum levels of astroglial S100beta and neuron-specific enolase in cirrhotic patients with and without hepatic encephalopathy [HE]. S100beta levels showed a significant increase in groups with HE stage 1 and 2 compared to both control and cirrhosis patients. However serum neuron-specific enolase levels were not significantly different between the studied groups. S100beta levels had a specificity of 91.3% and sensitivity of 51.7% for detection of HE from cirrhosis. Serum S100beta may be a useful surrogate marker for the diagnosis of mild cognitive impairment in cirrhotic patients before they progress to more advanced stages of HE
Saleh, A., Kamel, L., Ghali, A., Ismail, A. & El Khayat, H. (2007). Serum levels of astroglial S100-beta and neuron-specific enolase in hepatic encephalopathy patients. EMHJ - Eastern Mediterranean Health Journal, 13 (5), 1114-1123, 2007 http://www.who.int/iris/handle/10665/117356
JournalEMHJ - Eastern Mediterranean Health Journal, 13 (5), 1114-1123, 2007
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Kamel, L.; Saleh, A.; Morsy, A.; Ghali, A.; El Khayat, H. (2007)To address the role of the opioid system in the pathogenesis of hepatic encephalopathy [HE] we measured plasma met- enkephalin, beta -endorphin and leu- enkephalin in patients with different grades of HE compared to control subjects and patients with cirrhosis. Plasma met- enkephalin levels were significantly higher in patients with cirrhosis and all grades of HE than controls. Plasma beta levels were similar in the 3 groups. Plasma leu- enkephalin levels were significantly higher -endorphin in HE grades II, III and IV than in controls, patients ...