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Serum levels of astroglial S100-beta and neuron-specific enolase in hepatic encephalopathy patients

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Abstract
To find a reliable, noninvasive method for the diagnosis of cognitive impairment in patients with hepatic cirrhosis we measured serum levels of astroglial S100beta and neuron-specific enolase in cirrhotic patients with and without hepatic encephalopathy [‎HE]‎. S100beta levels showed a significant increase in groups with HE stage 1 and 2 compared to both control and cirrhosis patients. However serum neuron-specific enolase levels were not significantly different between the studied groups. S100beta levels had a specificity of 91.3% and sensitivity of 51.7% for detection of HE from cirrhosis. Serum S100beta may be a useful surrogate marker for the diagnosis of mild cognitive impairment in cirrhotic patients before they progress to more advanced stages of HE
Citation
Saleh, A., Kamel, L., Ghali, A., Ismail, A. & El Khayat, H. (‎2007)‎. Serum levels of astroglial S100-beta and neuron-specific enolase in hepatic encephalopathy patients. EMHJ - Eastern Mediterranean Health Journal, 13 (‎5)‎, 1114-1123, 2007 https://apps.who.int/iris/handle/10665/117356
Journal
EMHJ - Eastern Mediterranean Health Journal, 13 (‎5)‎, 1114-1123, 2007
Description
1114-1123
ISSN
1020-3397
Other Identifiers
http://applications.emro.who.int/emhj/1305/13_5_2007_1114_1123.pdf
Language
English
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