Evaluation of serodiagnostic tests for T.b. gambiense human African trypanosomiasis in southern Sudan
AbstractA survey was conducted in a low-endemic and in a non-endemic area of Sudan to evaluate the specificity and efficiency of different serological antibody detection techniques for Trypanosoma brucei gambiense. Comparisons were made of the card agglutination test for trypanosomiasis [CATT] on diluted blood, on diluted plasma and on eluates from blood dried on filter paper, the LATEX test on diluted plasma and an ELISA on diluted plasma and filter paper. The specificities of all the serological tests were not significantly different from CATT on diluted blood [99.5%]. The specificity of CATT on diluted blood was similar [99.3%]. The highest sensitivities [100%] were observed with CATT on diluted blood and with CATT and LATEX on diluted plasma. CATT on diluted blood was more cost-efficient than the classic test, CATT on whole blood
Elrayah, I.E., Rhaman, M.A., Karamalla, L.T., Khalil, K.M. & Buscher, P. (2007). Evaluation of serodiagnostic tests for T.b. gambiense human African trypanosomiasis in southern Sudan. EMHJ - Eastern Mediterranean Health Journal, 13 (5), 1098-1107, 2007 http://www.who.int/iris/handle/10665/117354
JournalEMHJ - Eastern Mediterranean Health Journal, 13 (5), 1098-1107, 2007
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Control of human african trypanosomiasis: a strategy for the African Region: report of the Regional Director Regional Committee for Africa, 55 (AFR/RC55/11, 2011-06-23)1. Human African trypanosomiasis (HAT) is caused by trypanosomes that are transmitted by the tsetse fly. HAT is the only vector-borne parasitic disease with a geographical distribution limited to the African continent. Populations in the age group 15-45 years living in remote rural areas are the most affected, leading to economic loss and social misery. 2. In the early 1960s, the prevalence of HAT had been reduced to very low levels (prevalence rate less than one case per 10 000 inhabitants). Unfortunately, due to lack of regular surveillance ...
Report on a meeting of the Product Development Team for African Trypanosomiasis Chemotherapy to review the comparative study of the 14-day versus the 7-day treatment of late stage t.b. gamiense African trypanosomiasis with eflornithine : WHO, Geneva, 14 July 1998 UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases; Product Development Team for African Trypanosomiasis Chemotherapy (TDR/DDR/98.1, 1998)