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Screening for beta-thalassaemia carriers in Egypt: significance of the osmotic fragility test

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Abstract
To estimate beta-thalassaemia carrier rate and to determine an accurate mass screening test, we tested 1000 randomly selected children aged 5-16 years from different geographical areas of Egypt. Microcytosis was present in 412 participants. The osmotic fragility test was positive in 81.1% of the 90 beta-thalassaemia carriers; in the indeterminate group [‎12 participants]‎, the test was positive in 83.3%; in the 310 who were iron deficient, the test was positive in 63.9%. beta-thalassaemia carrier rate was >/= 9%. Serum iron, microcytosis, HbA2 level and transferrin saturation were accurate tests for detecting carriers. For the one-tube osmotic fragility test, sensitivity was 87.0% and specificity 34.1%; the test has limited use for a mass screening programme in Egypt, where iron deficiency is prevalent
Citation
El Beshlawy, A., Kaddah, N., Moustafa, A., Mouktar, G. & Youssry, I. (‎2007)‎. Screening for beta-thalassaemia carriers in Egypt: significance of the osmotic fragility test. EMHJ - Eastern Mediterranean Health Journal, 13 (‎4)‎, 780-786, 2007 https://apps.who.int/iris/handle/10665/117312
Journal
EMHJ - Eastern Mediterranean Health Journal, 13 (‎4)‎, 780-786, 2007
Description
780-786
ISSN
1020-3397
Other Identifiers
http://applications.emro.who.int/emhj/1304/13_4_2007_780_786.pdf
Language
English
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