Platelet aggregation and physiological anticoagulants in sickle-cell disease
AbstractDuring the period January 2002- December 2004, we assessed 30 sickle- cell anaemia patients admitted to hospital in Al Khobar with vaso- occlusive crisis for levels of antithrombin [AT] III, protein C [PC] and protein S [PS]. We also did platelet aggregation studies. Steady state levels were assessed during follow- up and compared with 36 adult controls. Levels of PC, PS and AT III in the group were significantly higher than in those in vaso- occlusive crisis and those in steady state control [P < 0.001]. There was a statistically significant difference between controls and patients for all platelet factors except adrenaline. There was no significant difference between the levels of PC, PS, aggregation AT III and platelet aggregation variables in patients in the steady state and in vaso- occlusive crisi
Bashawri, L.A.M., Al Mulhim, A.A., Ahmed, M.A. & Bahnassi, A.A. (2007). Platelet aggregation and physiological anticoagulants in sickle-cell disease. EMHJ - Eastern Mediterranean Health Journal, 13 (2), 266-272, 2007 http://www.who.int/iris/handle/10665/117249
JournalEMHJ - Eastern Mediterranean Health Journal, 13 (2), 266-272, 2007
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Al Arrayed, Sheikha S.; Haites, Neva (1995)Genetic disorders of haemoglobin are prevalent in Bahrain. In a study of the hospital population covering 56 198 Bahrainis, we found that 2% of newborns have sickle-cell disease [SCD] and 18% have sickle-cell trait, while 24% are carriers of the [-thalassaemia gene. In a study of the presentation of SCD among Bahrainis it was found that the mild form of the disease predominates, but a wide clinical variability is apparent. It was also found that their haematological values are similar to those of patients from Eastern Province, Saudi Arabia, where ...