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dc.contributorKamel, L.EN
dc.contributorSaleh, A.EN
dc.contributorMorsy, A.EN
dc.contributorGhali, A.EN
dc.contributorEl Khayat, H.EN
dc.date.accessioned2014-06-17T07:58:21Z
dc.date.available2014-06-17T07:58:21Z
dc.date.issued2007EN
dc.identifier.issn1020-3397EN
dc.identifier.otherhttp://applications.emro.who.int/emhj/1302/13_2_2007_257_265.pdfEN
dc.identifier.urihttp://www.who.int/iris/handle/10665/117248
dc.description257-265EN
dc.description.abstractTo address the role of the opioid system in the pathogenesis of hepatic encephalopathy [‎HE]‎ we measured plasma met- enkephalin, beta -endorphin and leu- enkephalin in patients with different grades of HE compared to control subjects and patients with cirrhosis. Plasma met- enkephalin levels were significantly higher in patients with cirrhosis and all grades of HE than controls. Plasma beta levels were similar in the 3 groups. Plasma leu- enkephalin levels were significantly higher -endorphin in HE grades II, III and IV than in controls, patients with cirrhosis and HE grade I patients. Our results support data on the involvement of met- enkephalin and leu- enkephalin in the pathogenesis of HE and provide a rationale for the use of opioid receptor antagonists in the treatment of HEEN
dc.language.isoenEN
dc.subjectHepatic EncephalopathyEN
dc.subjectEnkephalin, MethionineEN
dc.subjectEnkephalin, LeucineEN
dc.subjectOpioid PeptidesEN
dc.subjectbeta-EndorphinEN
dc.subjectLiver Function TestsEN
dc.subject.meshHepatic EncephalopathyEN
dc.titlePlasma met-enkephalin, beta-endorphin and leu-enkephalin levels in human hepatic encephalopathyEN
dc.relation.ispartofjournalEMHJ - Eastern Mediterranean Health Journal, 13 (‎2)‎, 257-265, 2007


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