Plasma met-enkephalin, beta-endorphin and leu-enkephalin levels in human hepatic encephalopathy
RésuméTo address the role of the opioid system in the pathogenesis of hepatic encephalopathy [HE] we measured plasma met- enkephalin, beta -endorphin and leu- enkephalin in patients with different grades of HE compared to control subjects and patients with cirrhosis. Plasma met- enkephalin levels were significantly higher in patients with cirrhosis and all grades of HE than controls. Plasma beta levels were similar in the 3 groups. Plasma leu- enkephalin levels were significantly higher -endorphin in HE grades II, III and IV than in controls, patients with cirrhosis and HE grade I patients. Our results support data on the involvement of met- enkephalin and leu- enkephalin in the pathogenesis of HE and provide a rationale for the use of opioid receptor antagonists in the treatment of HE
Kamel, L., Saleh, A., Morsy, A., Ghali, A. & El Khayat, H. (2007). Plasma met-enkephalin, beta-endorphin and leu-enkephalin levels in human hepatic encephalopathy. EMHJ - Eastern Mediterranean Health Journal, 13 (2), 257-265, 2007 http://www.who.int/iris/handle/10665/117248
RevueEMHJ - Eastern Mediterranean Health Journal, 13 (2), 257-265, 2007
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Serum levels of astroglial S100-beta and neuron-specific enolase in hepatic encephalopathy patients Saleh, A.; Kamel, L.; Ghali, A.; Ismail, A.; El Khayat, H. (2007)To find a reliable, noninvasive method for the diagnosis of cognitive impairment in patients with hepatic cirrhosis we measured serum levels of astroglial S100beta and neuron-specific enolase in cirrhotic patients with and without hepatic encephalopathy [HE]. S100beta levels showed a significant increase in groups with HE stage 1 and 2 compared to both control and cirrhosis patients. However serum neuron-specific enolase levels were not significantly different between the studied groups. S100beta levels had a specificity of 91.3% and sensitivity ...