Coeliac disease in Sudanese children with clinical features suggestive of the disease
AbstractOur prospective hospital- based study examined frequency, clinical presentation and serological indicators of coeliac disease that correlated with intestinal biopsy among high- risk Sudanese children. From July 2001 to July 2002, 80 children aged 15 months- 18 years presented with poor appetite, weight loss, pallor and proximal muscle wasting. We diagnosed coeliac disease in 18 [22.5%]. Antigliadin antibodies [AGA- IgG, AGA- IgA or both] were high in 44; endomysial antibody retest was high in 30. Guardians of 12 children refused consent for biopsy. The other 18 were biopsied: 5 had total villous atrophy, 8 subtotal and 5 partial. All improved with gluten- free diet. Degree of villous atrophy did not correlate with diarrhoea duration or severity, anaemia severity or serological titres
Mohammed, I.M., Karrar, Z.E.A. & El Safi, S.H. (2006). Coeliac disease in Sudanese children with clinical features suggestive of the disease. http://www.who.int/iris/handle/10665/117122
EMHJ - Eastern Mediterranean Health Journal, 12 (5), 582-589, 2006
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