TY - GEN DP - http://iris.who.int/ DB - WHO IRIS AU - Anwar, M.M. AU - Youssef, A.I. AU - Sheta, M.I. AU - Zaki, A. AU - Bernaba, N.R. AU - El Toukhi, M.A. AB - The aim of the study was to assess the accuracy of some specific biochemical indicators in discriminating between Helicobacter pylori-associated gastritis and H. pylori-associated stomach cancer [serum gastrin level, serum soluble E-cadherin and tissue COX-2 activity, as well as serodiagnostic markers for H. pylori infection] in order to find a simple diagnostic test that can reasonably predict the development of gastric cancer. The study participants comprised 20 patients with gastric carcinoma, 20 patients with positive H. pylori-associated gastritis and 20 individuals as the control group. Standard procedures and quality control measures were followed. Using cut-off values and ROC analysis to assess the diagnostic abilities of the biochemical indicators, E-cadherin showed the highest sensitivity [100%]. We suggest that close follow-up together with periodic endoscopic examination for all patients with persistent H. pylori infection and serum soluble E-cadherin level above 5 microg/mL is essential LA - en UR - https://iris.who.int/handle/10665/118268 JF - EMHJ - Eastern Mediterranean Health Journal, 18 (5), 501-507, 2012 DA - 2012 PY - 2012 SE - 501-507 TI - Evaluation of specific biochemical indicators of Helicobactepylori-associated gastric cancer in Egypt KW - Stomach Neoplasms KW - Helicobacter pylori KW - Gastrins KW - Cadherins KW - Stomach Neoplasms KW - Gastritis KW - Sensitivity and Specificity KW - Stomach Neoplasms SN - 1020-3397 N2 - The aim of the study was to assess the accuracy of some specific biochemical indicators in discriminating between Helicobacter pylori-associated gastritis and H. pylori-associated stomach cancer [serum gastrin level, serum soluble E-cadherin and tissue COX-2 activity, as well as serodiagnostic markers for H. pylori infection] in order to find a simple diagnostic test that can reasonably predict the development of gastric cancer. The study participants comprised 20 patients with gastric carcinoma, 20 patients with positive H. pylori-associated gastritis and 20 individuals as the control group. Standard procedures and quality control measures were followed. Using cut-off values and ROC analysis to assess the diagnostic abilities of the biochemical indicators, E-cadherin showed the highest sensitivity [100%]. We suggest that close follow-up together with periodic endoscopic examination for all patients with persistent H. pylori infection and serum soluble E-cadherin level above 5 microg/mL is essential ER -