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    • Comparison of oral ibuprofen and indomethacin on closure of patent ductus arteriosus in preterm infants 

      Pourarian, Sh.; Pishva, N.; Madani, A.; Rastegari, M. (‎2008)‎
      Although intravenous indomethacin and ibuprofen are widely used for closure of patent ductus arteriosus in premature infants, these formulations are unavailable in the Islamic Republic of Iran. In this study of the therapeutic effects of oral treatments, 20 preterm infants were randomized to oral ibuprofen [‎1x10 mg/kg, then 2x5 mg/kg at 24-hour intervals]‎ or oral indomethacin [‎3 x 0.2 mg/kg at 24-hour intervals]‎. Complete ductal closure was seen in 7/10 of the indomethacin and 8/10 of the ibuprofen group. The difference was not significant. There ...