Lufenuron

Overview

Chemical Names
(RS)-1-[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy) phenyl]-3-(2,6-difluorobenzoyl)urea
CAS number
103055-07-8
JECFA number
85
Functional Class
Veterinary Drug
INSECTICIDE
Veterinary Drug

Evaluations

Evaluation year: 2017

ADI:
0–0.02 mg/kg bw

Comments:
Tonic–clonic seizures and findings in lungs, gastrointestinal tract, liver and urinary tract in rats ARfD: Unnecessary.
MRL Comment:
1350 μg/kg in salmon fillet (muscle plus skin in natural proportion)
Intake:
GECDE: 1.1 μg/kg bw per day as veterinary drug and 1.8 μg/kg bw per day for combined chronic dietary exposure from veterinary drug and pesticide residues (general population).
Report: 
JECFA 85 report

Toxicological study

Pivotal Study:
Two-year toxicity and carcinogenicity study (diet)
Animal Specie:
Rat
Effect:
Tonic–clonic seizures, histopathological effects on lungs, liver, non-glandular stomach, intestines and urinary tract.
NOAEL:
1.93 mg/kg bw per day
Previous Years:
Lufenuron had been evaluated by JMPR in 2015
Lufenuron had been evaluated by JMPR in 2015