Flumethrin
Overview
Chemical Names
(RS)-cyano-4-fluoro-3-phenoxybenzyl 3-(β,4-dichlorostyryl)-2,2-dimethylcyclopropanecarboxylate
CAS number
69770-45-2
JECFA number
85
Functional Class
Veterinary Drug
INSECTICIDE
Veterinary Drug
INSECTICIDE
Veterinary Drug
Evaluations
Evaluation year: 2019
ADI:0–0.004 mg/kg bw (2017)
ADI:
0–0.004 mg/kg bw (2017)
Comments:
The ADI established by the Committee at the 85th meeting remains unchanged. The ARfD of 0.005 mg/kg bw established by the Committee at the 85th meeting remains unchanged.
MRL Comment:
The Committee concluded that it would not be possible to recommend MRLs with the available data.
Intake:
No dietary exposure assessment was conducted because no MRLs were recommended.
Meeting:
88
Report:
Evaluation year: 2017
ADI:
0–0.004 mg/ kg bw
Comments:
Skin lesions in parental animals and reduced survival and body-weight gain in pups in a two generation toxicity study in rats.
ARfD: 0.005 mg/kg bw based on the rat developmental toxicity study
MRL Comment:
MRL for honey of 6 μg/kg which is twice the limit of quantification of the most reliable analytical method (liquid chromatography coupled with tandem mass spectrometry; LC–MS/MS) used in the residues studies.
Intake:
GECDE: 0.008 μg/kg bw per day (general population) and 0.006 μg/kg bw per day (Children).
GEADE: 0.1μg/kg bw per day (general population) and 0.1 μg/kg bw per day (Children).
Report:
Toxicological study
Animal Specie:
Rat
Effect:
Reduced pup survival and bodyweight gain. Maternal toxicity: Salivation
NOAEL:
0.37 mg/kg bw per day
Previous Years:
Previously evaluated by JMPR in 1996
Previously evaluated by JMPR in 1996