Ethion
Overview
Chemical Names
O,O,O′,O′-tetraethyl S, S′-methylene-bis (phosphorodithioate)
Synonyms
diethion
CAS number
563-12-2
JECFA number
85
Functional Class
Veterinary Drug
INSECTICIDE
Veterinary Drug
INSECTICIDE
Veterinary Drug
Evaluations
Evaluation year: 2019
ADI:0–0.002 mg/kg bw (2017)
ADI:
0–0.002 mg/kg bw (2017)
Comments:
The ADI established by the Committee at the 85th meeting remains unchanged. The ARfD of 0.02 mg/kg bw established by the Committee at the 85th meeting remains unchanged.
MRL Comment:
The Committee concluded that it would not be possible to recommend MRLs with the available data.
Intake:
No dietary exposure assessment could be conducted.
Meeting:
88
Report:
Residues:
Evaluation year: 2017
ADI:
0–0.002 mg/ kg bw
Comments:
Based on rat developmental toxicity study.
ARfD: 0.02 mg/kg bw based on erythrocyte AChE inhibition in the repeated-dose human study.
MRL Comment:
A suitable marker residue could not be determined.
The Committee was unable to recommend MRLs for ethion.
Intake:
No dietary exposure assessment could be conducted.
Report:
Toxicological study
Pivotal Study:
Developmental toxicity study (gavage) for chronic toxicity and three-week study of effects of ethion on erythrocyte AChE activity for acute toxicity.
Animal Specie:
Rat
Effect:
Embryotoxic effects
NOAEL:
0.2 mg/kg bw per day
Previous Years:
Ethion was previously evaluated by JMPR in 1968, 1972, 1986 and 1990.
Ethion was previously evaluated by JMPR in 1968, 1972, 1986 and 1990.