NON-DIOXIN-LIKE POLYCHLORINATED BIPHENYLS

General Information


Functional Class:
  • Food Contaminant
    • CONTAMINANT

Evaluations


Evaluation year: 2015
Comments: The Committee recognized that there are similarities in some of the reported effects for NDL-PCBs and that, ideally, risk estimates for combined exposure are desirable. The Committee concluded that this cannot be done on the basis of currently available data, but noted that the points of departure selected for derivation of the MOEs were particularly conservative, as they were based on effects on liver and thyroid that were not of clear toxicological significance, the changes were minimal and the lowest doses at which they were seen were used for the points of departure, combined with upper-bound estimates of body burden.
Intake: Estimates of international mean dietary exposure per capita for the sum of the six indicator PCBs were calculated by the Committee using concentration data submitted to the GEMS/Food contaminants database and consumption data from the GEMS/Food cluster diets. The range of estimated dietary exposure to the sum of the six indicator PCBs between clusters for the lower-bound scenario was 1–60 ng/kg bw per day. For upper-bound exposures, the range between clusters was 2–83 ng/kg bw per day. Fish was a major contributor to dietary exposure across the majority of the clusters, contributing up to about 90% of dietary exposure for one cluster. This was due to the higher concentration of NDL-PCBs in fish and/or the higher consumption of fish for the cluster.
Meeting: 80
Report: TRS 995-JECFA 80/43
Tox Monograph: FAS 71-S1-JECFA 80/6