MIXED Β-GLUCANASE and XYLANASE from DISPOROTRICHUM DIMORPHOSPORUM

Overview

Chemical Names
3-(1,3;1,4)-β-D-glucan 3(4)-glucanohydrolase (beta-glucanase); 1,4-beta-D-xylan xylanohydrolase (xylanase)
CAS number
62213-14-3; 9025-57-4
Functional Class
Food Additives
ENZYME_PREPARATION

Evaluations

Evaluation year: 2015

ADI:
NOT SPECIFIED

Comments:
ADI “not specified” when used in the applications specified and in accordance with good manufacturing practice.
Intake:
A comparison of the dietary exposure estimate of 0.7 mg TOS/kg bw per day with the highest dose tested of 199 mg TOS/kg bw per day gives an MOE of at least 280.
Meeting:
80
Specs Code:
N,T
Report: 
TRS 995-JECFA 80/28
Tox Monograph: 
FAS 71-JECFA 80/75
Specification: 
FAO JECFA Monographs 17-JECFA 80/35

Toxicological study

Pivotal Study:
No treatment-related adverse effects were seen at the highest dose tested (199 mg TOS/kg bw per day) in the 13-week study of oral toxicity in rats
Animal Specie:
Rat
NOAEL:
199 mg TOS/kg bw per day