1,4-alpha-D-glucan maltotetraohydrolase

Overview

Chemical Names
4-alpha-D-glucan maltotetraohydrolase; EC 3.2.1.60
Synonyms
Exo-maltotetraohydrolase; 1,4-alpha-D-glucan maltotetraohydrolase
Functional Class
Food Additives
ENZYME_PREPARATION

Evaluations

Evaluation year: 2015

ADI:
NOT SPECIFIED

Comments:
The Committee established an ADI “not specified” for maltotetraohydrolase from P. stutzeri expressed in B. licheniformis when used in the applications specified and in accordance with good manufacturing practice.
Intake:
A comparison of the dietary exposure estimate of 0.1 mg TOS/kg bw per day with the highest dose tested of 93.4 mg TOS/kg bw per day results in an MOE of at least 900.
Meeting:
80
Specs Code:
N
Tox Monograph: 

Toxicological study

Pivotal Study:
No treatment-related adverse effects were seen at the highest dose tested (93.4 mg TOS/kg bw per day) in the 13-week study of oral toxicity in rats
Animal Specie:
Rat
NOAEL:
93.4 mg TOS/kg bw per day