Mixed Β-GLUCANASE, CELLULASE and XYLANASE from RASAMSONIA EMERSONI

Overview

Chemical Names
3-(1,3;1,4)-β-D-glucan 3(4)-glucanohydrolase (beta-glucanase); 4-(1,3;1,4)--β--D-glucan 4-glucanohydrolase (cellulase); 1,4-beta-D-xylan xylanohydrolase (xylanase)
CAS number
62213-14-3; 9012-54-8; 9025-57-4
Functional Class
Food Additives
ENZYME_PREPARATION

Evaluations

Evaluation year: 2015

ADI:
NOT SPECIFIED

Comments:
ADI “not specified” when used in the applications specified and in accordance with good manufacturing practice.
Intake:
A comparison of the dietary exposure estimate of 0.08 mg TOS/kg bw per day with the highest dose tested of 84.8 mg TOS/kg bw per day results in an MOE of at least 1000.
Meeting:
80
Specs Code:
N,T
Report: 
TRS 995-JECFA 80/24
Tox Monograph: 
FAS 71-JECFA 80/63
Specification: 
FAO JECFA Monographs 17-JECFA 80/35

Toxicological study

Pivotal Study:
No treatment-related adverse effects were seen at the highest dose tested (84.8 mg TOS/kg bw per day) in a 13-week study of oral toxicity in rats.
Animal Specie:
Rats
NOAEL:
84.8 mg TOS/kg bw per day)