EMAMECTIN BENZOATE

Overview

CAS number
155569-91-8
Functional Class
Veterinary Drug
VETERINARY_DRUG

Evaluations

Evaluation year: 2013

ADI:
0–0.0005 mg/kg b.w.

Comments:
The Committee confirmed the ADI of 0–0.0005 mg/kg body weight established by the Joint FAO/WHO Meeting on Pesticide Residues (JMPR) in 2011, based on an overall no-observed-adverse-effect level (NOAEL) of 0.25 mg/kg body weight per day for neurotoxicity from 14- and 53-week studies in dogs, supported by an overall NOAEL of 0.25 mg/kg body weight per day from 1- and 2-year studies in rats. An uncertainty factor of 500 was applied to the NOAEL, which includes an additional uncertainty factor of 5 to account for the steep dose–response curve and irreversible histopathological effects in neural tissues at the lowest-observed-adverse-effect level (LOAEL) in dogs, as used by JMPR and confirmed by the current Committee.
Intake:
The EDI is 11 μg/person per day, which represents approximately 37% of the upper bound of the ADI.
Meeting:
78
Report: 
TRS 988-JECFA 78/
Tox Monograph: 
FAS 69-JECFA 78/