SERINE PROTEASE (CHYMOTRYPSIN) from NOCARDIOPSIS PRASINA expressed in BACILLUS LICHENIFORMIS

Overview

Chemical Names
Chymotrypsin: (EC 3.4.21.1)
Functional Class
Food Additives
ENZYME_PREPARATION

Evaluations

Evaluation year: 2012

ADI:
NOT SPECIFIED

Comments:
Comparing the exposure estimate with the NOAEL from the 13-week study of oral toxicity in rats, the margin of exposure is approximately 350. The Committee allocated an ADI “not specified”b for serine protease (chymotrypsin) enzyme preparation from N. prasina expressed in the production strain B. licheniformis, used in the applications specified and in accordance with good manufacturing practice.
Specs Code:
N
Report: 
TRS 974 JECFA 76/19
Tox Monograph: 
FAS 67 JECFA 76
Specification: 
FAO Combined Compendium of Food Additive Specifications