TIN

Overview

CAS number
7440-31-5
Functional Class
Food Contaminant
METALS

Evaluations

Evaluation year: 2006

Comments:
At its present meeting, the Committee reconsidered studies of the acute toxic effects seen in humans after consumption of foods containing high concentrations of inorganic compounds of tin, and also considered a new study. The Committee concluded that the data available indicated that it is inappropriate to establish an ARfD for inorganic tin, since the occurence of GI-irritation after ingestion of a food containing tin depends on the concentration and nature of tin in the product, rather than on the dose ingested on a body-weight basis. Therefore, short-term intake estimates were not relevant for the assessment. The Committee reiterated the opinion expressed at its 33rd and 55th meetings that the available data for humans indicated that inorganic tin concentrations of >150 mg/kg in canned beverages or 250 mg/kg in canned foods may produce acute gastric irritation in certain individuals. Therefore ingestion of food containing inorganic tin at concentrations equal to the proposed standard for canned beverages (200 mg/kg) may lead to adverse reactions. The Committee reiterated its advice that consumers should not store food and beverages in opened tinplated cans. In addition, the Committee noted that the basis for the PMTDI and PTWI established at its 26th and 33rd meetings was unclear and these values may have been derived from intakes associated with acute effects. The Committee concluded that it was desirable to (re)assess the toxicokinetics and effects of inorganic tin after long-term exposure to dietary doses of inorganic tin at concentrations that did not elicit acute effects.
Intake:
Chronic mean intake: < 1-14 mg/d. Short-term mean intake: 0.004-3.3 mg/kg bw/d.
Tolerable Intake:
PTWI 14 mg/kg bw (1988)
Meeting:
64
Previous Years:
2000, TRS 901-JECFA 55/69, FAS 24-JECFA 33/329 (1988). THE PTWI, EXPRESSED AS SN, INCLUDES TIN FROM FOOD ADDITIVE USES. THE 1988 PTWI WAS NOT RECONSIDERED AND WAS MAINTAINED AT THE FIFTY-FIFTH MEETING (2000). THE ACUTE TOXICITY OF TIN WAS ASSESSED AT THE
2000, TRS 901-JECFA 55/69, FAS 24-JECFA 33/329 (1988). THE PTWI, EXPRESSED AS SN, INCLUDES TIN FROM FOOD ADDITIVE USES. THE 1988 PTWI WAS NOT RECONSIDERED AND WAS MAINTAINED AT THE FIFTY-FIFTH MEETING (2000). THE ACUTE TOXICITY OF TIN WAS ASSESSED AT THE