2-BUTYRYLFURAN

Overview

Chemical Names

2-BUTYRYLFURAN

Synonyms

1-(2-FURYL)-1-BUTANONE; 2-FURYL PROPYL KETONE; FURYL N-PROPYL KETONE

CAS number

100113-53-9

JECFA number

1507

COE number

13105

FEMA number

4083

Functional Class

Flavouring Agent
FLAVOURING_AGENT

Evaluations

Evaluation year: 2018

ADI:
No safety concern at current levels of intake when used as a flavouring agent

Meeting:

Specs Code:

Report:

">TRS 1014-JECFA 86/84

Tox Monograph:

FAS 77 JECFA 86/379

Specification:

FAO JECFA Monographs 22/99

Evaluation year: 2005

Comments:

The Committee took note of the extensive positive genotoxicity data for several members of this group of flavouring agents related to furan. Furan, which is carcinogenic, is known to undergo epoxidation and ring opening to form a reactive 2-ene-1,4-dicarbonyl intermediate. Accordingly, concern arises that the observed genotoxicity may be due to formation of a reactive metabolite. Data on the potential of members of this group to form a reactive metabolite were not available and the role of metabolism in the observed genotoxicity has not been identified. Moreover, there was a paucity of in vivo genotoxicity data to allay concern. Also, specific in vivo assays to address potential carcinogenicity were lacking. Because of these concerns, the Committee concluded that the Procedure for the Safety Evaluation of Flavouring Agents could not be applied to this group.

Report:

TRS 934-JECFA 65/42