(+)-CARVONE

Overview

Chemical Names
p-MENTHA-6,8-DIEN-2-ONE
Synonyms
d-CARVONE; DEXTRO-CARVONE
JECFA number
380a; 380.1
COE number
146
FEMA number
2249
Functional Class
Flavouring Agent
FLAVOURING_AGENT

Evaluations

Evaluation year: 2018

Comments:
The Committee did not re-evaluate (+)-carvone (No. 380.1) according to the revised Procedure for the Safety Evaluation of Flavouring Agents given the lack of information on the oral exposure from all sources and the need to review the ADI. A review of the ADI is recommended based on the evaluation of all biochemical and toxicological data. Also, data are needed for an exposure assessment for oral exposure to (+)-carvone from all sources to complete the evaluation for (+)-carvone.
Meeting:
86
Specs Code:
M
Report: 
">TRS 1014-JECFA 86/78
Tox Monograph: 
FAS 77 JECFA 86/361
Specification: 
FAO JECFA Monographs 22/99

Evaluation year: 1998

ADI:
0-1 mg/kg bw (1990)
Comments:
No safety concern at current levels of intake when used as a flavouring agent. The 1990 ADI of 0-1 mg/kg bw was maintained at the fifty-first meeting (1998).
Report: 
TRS 891-JECFA 51/90
Tox Monograph: 
FAS 42-JECFA 51/319
Specification: 
COMPENDIUM ADDENDUM 6/FNP 52 Add.6/182
Previous Years:
1990, TRS 806-JECFA 37/18, COMPENDIUM/405, FAS 28-JECFA 37/155. 0-1 FU R 1988, TRS 776-JECFA 33/17, FNP 38-JECFA 33/57, FAS 14-JECFA 23/16 (1979). 0-1.0 (TEMPORARY; ADI APPLIES TO d-CARVONE OR l-CARVONE, ALONE OR IN COMBINATION). TE. R 1986, TRS 751-JECFA 30/19, FNP 37-JECFA 30/29, FAS 14-JECFA 23/16 (1979). 0-1 (TEMPORARY; ADI APPLIES TO d-CARVONE OR l-CARVONE, ALONE OR IN COMBINATION). TE. R. 1983, TRS 696-JECFA 27/18, FNP 28-JECFA 27/25, FAS 14-JECFA 23/16 (1979). 0-1 (TEMPORARY; AS THE SUM OF THE ISOMERS). TE. R 1981, TRS 669-JECFA 25/21, FNP 19-JECFA 25/71, FAS 14-JECFA 23/16 (1976). 0-1 (TEMPORARY). TE. R 1979, TRS 648-JECFA 23/24, FNP 12-JECFA 23/19, FAS 14-JECFA 23/16. 0-1 (TEMPORARY). TE. R 1967, NMRS 44/TRS 383-JECFA 11/12, FAS 69.31/NMRS 44B-JECFA 11/8, FAS 68.33/NMRS 44A-JECFA 11/14. 0-1.25 (CONDITIONAL). CO. N
1990, TRS 806-JECFA 37/18, COMPENDIUM/405, FAS 28-JECFA 37/155. 0-1 FU R 1988, TRS 776-JECFA 33/17, FNP 38-JECFA 33/57, FAS 14-JECFA 23/16 (1979). 0-1.0 (TEMPORARY; ADI APPLIES TO d-CARVONE OR l-CARVONE, ALONE OR IN COMBINATION). TE. R 1986, TRS 751-JECFA 30/19, FNP 37-JECFA 30/29, FAS 14-JECFA 23/16 (1979). 0-1 (TEMPORARY; ADI APPLIES TO d-CARVONE OR l-CARVONE, ALONE OR IN COMBINATION). TE. R. 1983, TRS 696-JECFA 27/18, FNP 28-JECFA 27/25, FAS 14-JECFA 23/16 (1979). 0-1 (TEMPORARY; AS THE SUM OF THE ISOMERS). TE. R 1981, TRS 669-JECFA 25/21, FNP 19-JECFA 25/71, FAS 14-JECFA 23/16 (1976). 0-1 (TEMPORARY). TE. R 1979, TRS 648-JECFA 23/24, FNP 12-JECFA 23/19, FAS 14-JECFA 23/16. 0-1 (TEMPORARY). TE. R 1967, NMRS 44/TRS 383-JECFA 11/12, FAS 69.31/NMRS 44B-JECFA 11/8, FAS 68.33/NMRS 44A-JECFA 11/14. 0-1.25 (CONDITIONAL). CO. N