DIFURFURYL ETHER

Overview

Chemical Names
DIFURFURYL ETHER
Synonyms
FURFURYL ETHER
CAS number
4437-22-3
JECFA number
1522
COE number
13061
FEMA number
3337
Functional Class
Flavouring Agent
FLAVOURING_AGENT

Evaluations

Evaluation year: 2018

ADI:
No safety concern at current levels of intake when used as a flavouring agent

Meeting:
86
Specs Code:
M
Report: 
">TRS 1014-JECFA 86/84
Tox Monograph: 
FAS 77 JECFA 86/379
Specification: 
FAO JECFA Monographs 22/99

Evaluation year: 2012

Comments:
The Committee concluded that the Procedure could not be applied to this group because of unresolved toxicological concerns. Studies that could assist in the safety evaluation include investigations of the influence of the nature and position of furan ring substitutions on metabolism and covalent binding to macromolecules, demonstration of the ring opening and reactivity of the resulting products. Depending on the findings, additional genotoxicity or other studies might be needed.
Specs Code:
M
Report: 
TRS 974-JECFA 76
Specification: 
Compendium of FAO food additive specifications

Evaluation year: 2005

Comments:
The Committee took note of the extensive positive genotoxicity data for several members of this group of flavouring agents related to furan. Furan, which is carcinogenic, is known to undergo epoxidation and ring opening to form a reactive 2-ene-1,4-dicarb
Report: 
TRS 934-JECFA 65/42
Tox Monograph: 
FAS 56-JECFA 65
Specification: 
COMPENDIUM ADDENDUM 13/FNP 52 Add. 13/59