QUINOLINE YELLOW

Overview

Chemical Names
DISODIUM 2-(1,3-DIOXO-2-INDANYL)-6,8-QUINOLINESULFATES; DISODIUM 2-(2-QUINOLYL)- INDAN-1,3-DIONESULFONATES
Synonyms
C.I. FOOD YELLOW 13
CAS number
8004-92-0
INS
104
Functional Class
Food Additives
COLOUR
INS matches
104

Evaluations

Evaluation year: 2016

ADI:
0–3 mg/kg bw

Comments:
The Committee concluded that it was reasonable to use toxicology data on D&C Yellow No. 10 to support the database for Quinoline Yellow. The Committee established an ADI of 0–3 mg/kg bw (rounded value) for Quinoline Yellow on the basis of a NOAEL of 250 mg/kg bw per day for effects on body weight and organ weights in two long-term studies in rats on D&C Yellow No. 10. An uncertainty factor of 100 was applied to account for interspecies and intraspecies variability. The Committee concluded that dietary exposure to Quinoline Yellow for children and all other age groups does not present a health concern.
Meeting:
82
Specs Code:
R
Tox Monograph: 

Evaluation year: 2011

ADI:
0–5 mg/kg body weight
Comments:
The Committee established a temporary ADI of 0–5 mg/kg body weight, incorporating an additional 2-fold safety factor, pending submission of requested toxicological studies by the end of 2013. The previously established ADI of 0–10 mg/kg body weight was withdrawn. The conservative exposure estimates were within the range of the temporary ADI. Additional information on the composition of the product in commerce is required, in particular relating to the identity and purity of the unmethylated form of Quinoline Yellow.
Specs Code:
T

Evaluation year: 1984

ADI:
0-10 mg/kg bw
Meeting:
28
Specs Code:
R
Previous Years:
1984, FNP 31/1-JECFA 28/117. R; COMPENDIUM/1249 1982, TRS 683-JECFA 26/24, FNP 25-JECFA 26/163. 0-0.5 (TEMPORARY). TE. R,T 1978, TRS 631-JECFA 22/20, FAS 13-JECFA 22/19. 0-0.5 (TEMPORARY). TE. S,T 1977, NMRS 57-JECFA 25/98. R,T 1975, NMRS 55/TRS 576-J
1984, FNP 31/1-JECFA 28/117. R; COMPENDIUM/1249 1982, TRS 683-JECFA 26/24, FNP 25-JECFA 26/163. 0-0.5 (TEMPORARY). TE. R,T 1978, TRS 631-JECFA 22/20, FAS 13-JECFA 22/19. 0-0.5 (TEMPORARY). TE. S,T 1977, NMRS 57-JECFA 25/98. R,T 1975, NMRS 55/TRS 576-J