NATAMYCIN

Overview

Chemical Names
A stereoisomer of 22-(3-amino-3,6-dideoxy-9-d-mannopyranosyloxy)-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.o^5,7]octacosa-8,14,16,18,20-pentane-25-carboxylic acid
Synonyms
Pimaricin
CAS number
7681-93-8
INS
235
Functional Class
Food Additives
PRESERVATIVE
INS matches
235

Evaluations

Evaluation year: 2006

ADI:
0-0.3 mg/kg bw (1976)

Comments:
Natamycin considered for dietary exposure only.
MRL Comment:
In 2006 in a exposure assessment JECFA noted that the data as a whole, including estimations based on GEMS/Food Consumption Cluster Diets and calculations for consumers with a high intake and children, confirm the results of the assessment made by the Committee at its fifty-seventh meeting and show that the current ADI of 0-0.3 mg/kg bw is unlikely to be exceeded.
Meeting:
67
Tox Monograph: 
FAS 58-JECFA 67/339

Evaluation year: 2001

ADI:
0-0.3 mg/kg bw (1976)
Comments:
JECFA confirmed the previously established ADI of 0-0.3 mg/kg bw.
Meeting:
57
Specs Code:
R
Report: 
TRS 909-JECFA 57/25 (2001)
Tox Monograph: 
FAS 48-JECFA 57/49
Specification: 
FAO Combined Compendium of Food Additive Specifications
Previous Years:
2001, COMPENDIUM ADDENDUM 9/FNP 52 Add.9/71. R,T 1976, FNS 1/TRS 599-JECFA 20/16, FAS 11/FNS 1B-JECFA-20/62; COMPENDIUM/1083, FAS 10-JECFA 20/76. 0-0.3 mg/kg bw. FU. R 1973, FNP 4-JECFA 17/137. R 1968, NMRS 45/TRS 430-JECFA 12/27, FAS 69.34/NMRS 45A-JE
2001, COMPENDIUM ADDENDUM 9/FNP 52 Add.9/71. R,T 1976, FNS 1/TRS 599-JECFA 20/16, FAS 11/FNS 1B-JECFA-20/62; COMPENDIUM/1083, FAS 10-JECFA 20/76. 0-0.3 mg/kg bw. FU. R 1973, FNP 4-JECFA 17/137. R 1968, NMRS 45/TRS 430-JECFA 12/27, FAS 69.34/NMRS 45A-JE