DOCUSATE SODIUM

Overview

Chemical Names
Dioctyl sodium sulfosuccinate; Sodium 1,4-bis-(2-ethylhexyl)-sulfosuccinate
Synonyms
DSS; Docusate sodium
CAS number
577-11-7
INS
480
Functional Class
Food Additives
EMULSIFIER
HUMECTANT
INS matches
480

Evaluations

Evaluation year: 1995

ADI:
0-0.1 mg/kg bw

Comments:
JECFA concluded that dioctyl sodium sulfosuccinate could be evaluated on the basis of the limited data available because of the low intake anticipated from food additive uses, and consequently withdrew its request for a long-term study. However, because of the limited toxicological database on dioctyl sodium sulfosuccinate, JECFA increased the previous safety factor of 200 to 500. On the basis of a NOEL of 50 mg/kg bw from a reproductive study in rats and new safety factor of 500, JECFA established an ADI of 0-1.1 mg/kg bw for the food additive of dioctyl sodium sulfosuccinate.
Meeting:
44
Specs Code:
S
Report: 
TRS 859-JECFA 44/10
Tox Monograph: 
FAS 28-JECFA 37/275 (1990)
Specification: 
FAO Combined Compendium of Food Additive Specifications
Previous Years:
1990, TRS 806-JECFA 37/24, COMPENDIUM/521. 0-0.25 (TEMPORARY). TE. R 1983, FNP 28-JECFA 27/37. R 1980, TRS 653-JECFA 24/25, FNP 17-JECFA 24/36. NO ADI ALLOCATED. NO. R 1978, TRS 631-JECFA 22/22, FNP 7-JECFA 22/30. NO ADI ALLOCATED. NO. R,T 1974, NMRS
1990, TRS 806-JECFA 37/24, COMPENDIUM/521. 0-0.25 (TEMPORARY). TE. R 1983, FNP 28-JECFA 27/37. R 1980, TRS 653-JECFA 24/25, FNP 17-JECFA 24/36. NO ADI ALLOCATED. NO. R 1978, TRS 631-JECFA 22/22, FNP 7-JECFA 22/30. NO ADI ALLOCATED. NO. R,T 1974, NMRS