COPPER

Overview

CAS number
7440-50-8
Functional Class
Food Contaminant
METALS

Evaluations

Evaluation year: 1982

Comments:
The level of copper in food meets the nutritional requirements (2-3 mg/day for adults; 0.5-0.7 mg/day for infants). Copper is not carcinogenic in either humans or animals, and copper salts are not embryotoxic in rodents. Highly-exposed populations do not appear to be adversely affected, nor does copper appear to be a cumulative toxic hazard for man, except for individuals with Wilson's disease. On this basis, the previous tentative evaluation of a maximum daily load of 0.5 mg/kg bw was reaffirmed as a provisional value for a maximum tolerable intake of 0.5 mg/kg bw per day from all sources.
Tolerable Intake:
PMTDI 0.5 mg/kg bw per day
Meeting:
26
Report: 
TRS 683-JECFA 26/31
Tox Monograph: 
FAS 17-JECFA 26/265

Toxicological study

PMTDI:
0.5 mg/kg bw
Previous Years:
1970, NMRS 48/TRS 462-JECFA 14/18, FAS 70.39/NMRS 48A-JECFA 14/32. NO ADI. NO 1966, NMRS 43/TRS 373-JECFA 10/15. 0.5 (TENTATIVE MAXIMUM ACCEPTABLE DAILY LOAD). TE
1970, NMRS 48/TRS 462-JECFA 14/18, FAS 70.39/NMRS 48A-JECFA 14/32. NO ADI. NO 1966, NMRS 43/TRS 373-JECFA 10/15. 0.5 (TENTATIVE MAXIMUM ACCEPTABLE DAILY LOAD). TE