beta-CYCLODEXTRIN

Overview

Chemical Names
Cycloheptaamylose
Synonyms
BCD; beta-Schardinger dextrin; Cyclodextrin B
INS
459
Functional Class
Food Additives
ADJUVANT
INS matches
459

Evaluations

Evaluation year: 1995

ADI:
0-5 mg/kg bw

Comments:
JECFA revised the previous temporary ADI (0-6 mg/kg bw) and allocated an ADI of 0-5 mg/kg bw for beta-cyclodextrin based on a NOEL of 1.25% in the diet (equal to 470 mg/kg bw/day) in a 1-year study in dogs and a safety factor of 100.
Report: 
TRS 859-JECFA 44/28
Tox Monograph: 
FAS 35-JECFA 44/257
Specification: 
FAO Combined Compendium of Food Additive Specifications
Previous Years:
1995, COMPENDIUM ADDENDUM 3/FNP 52 Add.3/55. R 1993, TRS 837-JECFA 41/23, COMPENDIUM ADDENDUM 2/FNP 52 Add.2/33, FAS 32-JECFA 41/173. 0-6 (TEMPORARY). TE. N,T
1995, COMPENDIUM ADDENDUM 3/FNP 52 Add.3/55. R 1993, TRS 837-JECFA 41/23, COMPENDIUM ADDENDUM 2/FNP 52 Add.2/33, FAS 32-JECFA 41/173. 0-6 (TEMPORARY). TE. N,T