ADIPIC ACID

Overview

Chemical Names
Hexanedioic acid; 1,4-Butanedicarboxilic acid
CAS number
124-04-9
JECFA number
623
INS
355
COE number
26
FEMA number
2011
Functional Class
Flavouring Agent
FLAVOURING_AGENTFood Additives
ACIDITY_REGULATOR
INS matches
355

Evaluations

Evaluation year: 1999

ADI:
0-5 mg/kg bw (General use, 1977); No safety concern at current levels of intake when used as a flavouring agent (Flavour use, 1999)

Comments:
General use (1977): Group ADI of 0-5 mg/kg bw for adipic acid and its potassium, sodium and ammonium salts.
Meeting:
21
Specs Code:
S (1977)
Tox Monograph: 

Evaluation year: 1977

ADI:
0-5 mg/kg bw
Comments:
JECFA noted that in a two-year study that adipic acid causes diarrhoea in rats. The no-effect level in this study was 1% of the diet. An ADI of 0-5 mg/kg bw was established on the bases of the free acid. The is applicable to the potassium, sodium and ammonium salts as well as the free acid.
Meeting:
21
Specs Code:
O
Tox Monograph: 
Previous Years:
FU 1975, NMRS 55B/FAS 9-JECFA 19/6 (COMPENDIUM/25). R 1965, NMRS 40/TRS 339-JECFA 9/16, FAS 67.29/NMRS 40A,B,C-JECFA 9/129, FAS 67.29/NMRS 40A,B,C-JECFA 9/129. 0-5 (CONDITIONAL). CO. N
FU 1975, NMRS 55B/FAS 9-JECFA 19/6 (COMPENDIUM/25). R 1965, NMRS 40/TRS 339-JECFA 9/16, FAS 67.29/NMRS 40A,B,C-JECFA 9/129, FAS 67.29/NMRS 40A,B,C-JECFA 9/129. 0-5 (CONDITIONAL). CO. N