NITROFURAL

Overview

Chemical Names
2-[(5-NITRO-2-FURANYL)METHYLENE]-HYDRAZINECARBOXAMIDE; 5-NITRO-2-FURALDEHYDE SEMICARBAZONE
Synonyms
NITROFURAZONE
CAS number
59-87-0
Functional Class
Veterinary Drug
ANTIMICROBIAL_AGENT

Evaluations

Evaluation year: 1993

ADI:
NO ADI ALLOCATED

Comments:
The Committee concluded that it could not establish an ADI for nitrofural because no-effect levels had not been established for the tumorigenic effects. Although a no-effect level (15 mg/kg bw/day) had been established in rats for testicular hypoplasia in a 13-week study, a slightly lower dose (11 mg/kg bw/day) resulted in a high incidence of testicular degeneration in the 2-year carcinogenicity study. There was no NOEL for this effect in the 2-year study and, moreover, no study on reproductive performance was available. The degenerative changes in the joints of rats were seen in both males and females but a no-effect level could not be established.
MRL Comment:
No MRLs allocated due to: no ADI established & insufficient residue data
MRL Code:
O
Intake:
none calculated
Meeting:
40
Report: 
TRS 832-JECFA 40/37
Tox Monograph: 
FAS 31-JECFA 40/125
Residues: 
FNP 41/5-JECFA 40/105