Neohesperidin Dihydrochalcone

Overview

Chemical Names
Neohesperidin dihydrochalcone
Synonyms
NHDC
CAS number
20702-77-6
INS
959
Functional Class
Food Additives
SWEETENER
INS matches
959

Evaluations

Evaluation year: 2026

ADI:
Temporary ADI of 0–3.8 mg/kg bw per day

Comments:
JECFA established a temporary ADI (pending the submission of a reproductive toxicity study that assesses the reproductive capacity of the F1 generation) of 0–3.8 mg/kg bw per day for NHDC by applying a 200-fold uncertainty factor to the NOAEL of 760 mg/kg bw per day from a 90-day oral toxicity study in rats.
Intake:
JECFA considered the dietary exposure estimate of 1.8 mg/kg bw per day, the upper end of the range of high exposures in children, appropriate for the safety evaluation of NHDC. The dietary exposure for NHDC of 1.8 mg/kg bw per day is below the temporary ADI and does not represent a safety concern for the proposed uses and the proposed maximum levels.
Meeting:
102
Specs Code:
N, T