ADIPIC ACID

Comments:

Considered for exposure only.

Intake:

JECFA noted that the estimates of dietary exposure calculated at the current meeting are overestimated for a number of reasons. JECFA concluded that most of these conservative dietary exposure estimates greatly exceed the current group ADI of 0–5 mg/kg bw. Further, JECFA noted that there is the potential for exceedances of the current group ADI as a result of normal daily consumption amounts of an individual food. JECFA noted that hazard assessment procedures have evolved and additional relevant data may have become available since the numerical ADI was established at its Ninth meeting in 1965, indicating that a re-evaluation of the toxicology of adipic acid is needed.

Meeting:

100

Report: 

Tox Monograph: 

Specification: 

ADI:

0-5 mg/kg bw (General use, 1977); No safety concern at current levels of intake when used as a flavouring agent (Flavour use, 1999)

Comments:

General use (1977): Group ADI of 0-5 mg/kg bw for adipic acid and its potassium, sodium and ammonium salts.

Meeting:

21

Specs Code:

S (1977)

Report: 

Tox Monograph: 

Specification: 

ADI:

0-5 mg/kg bw

Comments:

JECFA noted that in a two-year study that adipic acid causes diarrhoea in rats. The no-effect level in this study was 1% of the diet. An ADI of 0-5 mg/kg bw was established on the bases of the free acid. The is applicable to the potassium, sodium and ammonium salts as well as the free acid.

Meeting:

21

Specs Code:

O

Report: 

Tox Monograph: 

Previous Years: